Anti-inflammatory Library
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چکیده
active agents are currently approved for market or under active investigation in different clinical trials. However, recent findings have exposed the fatal side effects directly associated with drugtherapy based on COX-2 inhibition. Considering these possible harmful outcomes, a range of novel therapeutically relevant biological targets which particularly includes NF-κB and JAK/STAT signaling pathways has received a growing attention. Here we present our original anti-inflammatory (AI) focused library which includes small molecule compounds targeted specifically against the biological targets just mentioned.
منابع مشابه
Anti-inflammatory Library
Preamble The accumulated scientific knowledge has already revealed key biological targets, such as COX2, and related pro-inflammatory mediators (cytokines and chemokines, ILs, TNF-α, MIF, IFN-γ, MMPs) implicated in uncontrolled, destructive inflammatory reaction. A number of physiologically active agents are currently approved for market or under active investigation in different clinical tria...
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